Hematopoietic Growth Factors for Blood Cell Growth and Maturation

Generic Names(s)                       Therapeutic                     Manufacturer/

(Brand Name)                                      Category                          Distributor

 

EPO, Erythropoietin                             Erythropenia                    Janssen-Ortho

Recombinant Human                             (red cell anemia);             (Johnson & Johnson)

Erythropoietin,                                    stimulates                       

Glycosylated,                                      production of                   (Amgen)

r-HuEPO,                                             red blood cells                          

Epoetin alfa

(Eprex®)

 

EPO, Recombinant                               As above                          Roche

Human Erythropoietin,                                                                Boehringer

Glycosylated,                                                                             Mannheim

r-HuEPO,

Epoetin beta

(Recorman®)

 

Novel Erythropoiesis                            As above                          Amgen

Stimulating Protein,

NESP

 

G-CSF, Filgrastim,                      Neutropenia;                             Amgen

Recombinant Human                   stimulates

Granulocyte Colony                    production of

Stimulating Factor,                     granulocytes/

Nonglycosylated,                        neutrophils

r-HuG-CSF                                 (white blood cells)

(Neupogen®)

 

G-CSF, Lenograstim,                            As Above                         Chugai and RhonePoulenc / Rorer

Recombinant Human                                                                  

Granulocyte Colony                                                          

Stimulating Factor,

Glycosylated,

r-HuG-CSF

(Granocyte®;

Neutrogin®)

 


Recombinant Hematopoietic Growth Factors

 

Generic Names(s)                       Therapeutic                     Manufacturer/

(Brand Name)                             Category                          Distributor

 

GM-CSF, Sargramostim,               Neutropenia and               Schering-Plough

Recombinant Human                   PBSCT; stimulates             (Immunex)

Granulocyte                               the production of            

Macrophage Colony                    granulocytes/mono

Stimulating Factor,                     phils and

Glycosylated,                             macrophages/mono

RHuGMCSF                                 cytes (white blood

                                                cells)

(Leukine®)

 

TPO, Recombinant                      Thrombocytopenia;          Pharmacia & Upjohn

Human Thrombopoietin,             stimulates production                

r-Hu-TPO                                   of platelets                      (Genentech)

 

MGDF, Recombinant                             As above                          Amgen

Human Magakaryocyte

Growth and

Development Factor,

r-HuMGDF

 

IL-11, Oprelvekin;                      As above                          Genetics Institute

Recombinant Human                                                                  

Interleukin-11,

r-Hu-IL11

(Neumega®)